The PI3K AKT signalling pathway
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The PI3K AKT signalling pathway
In this video, The PI3K/AKT/mTOR pathway is explained. The PI3K/AKT/mTOR pathway is an intracellular signalling pathway important in apoptosis and hence cancer e.g. breast cancer and non-small-cell...
Oct 20, 2011
PI3K/Akt/mTOR Pathway Cancer
Cancer does not start on a scan. Long before a tumor is visible, metabolic signaling is already shifting. One of the earliest patterns we see? Insulin resistance. Insulin is not just a blood sugar hormone — it is a growth factor. Chronically elevated insulin: • Activates the PI3K/Akt/mTOR pathway • Increases IGF-1 signaling • Promotes cellular proliferation • Inhibits apoptosis Large prospective cohort studies have linked hyperinsulinemia with increased risk of colorectal, breast, pancreatic, an
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Cancer does not start on a scan. Long before a tumor is visible, metabolic signaling is already shifting. One of the earliest patterns we see? Insulin resistance. Insulin is not just a blood sugar hormone — it is a growth factor. Chronically elevated insulin: • Activates the PI3K/Akt/mTOR pathway • Increases IGF-1 signaling • Promotes cellular proliferation • Inhibits apoptosis Large prospective cohort studies have linked hyperinsulinemia with increased risk of colorectal, breast, pancreatic, an
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