NFL, 49ers and Arizona Cardinals
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The San Francisco 49ers have been able to maintain a good run defense even when their pass defense has fallen apart. The team still ranks 11th overall in expect
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How did 49ers win vs. Cardinals impact San Francisco's standing in new NFL power rankings?
The San Francisco 49ers beat the Arizona Cardinals on Sunday at State Farm Stadium. How did it affect their standing heading into Week 12?
San Francisco 49ers QB Brock Purdy and his favorite target George Kittle have benefitted from their connection in more ways than one over the years
Jason Pinnock was benched after Week 5, but he has played 80 snaps in the 49ers' dime look since then. However, he has not been good in that role. Pinnock allowed five catches, including a touchdown, in his expanded role against the Arizona Cardinals. That should signal a time to switch things up, as he was one of the few issues in that game.
CBS Sports draft analyst Mike Renner has released his fourth 2026 NFL mock draft, projecting that the San Francisco 49ers will address one of their most pressing needs.
Arizona had the passing game working, but it didn't matter in a 41-22 loss to San Francisco at State Farm Stadium in Glendale.
Kickoff from State Farm Stadium is set for 4:25 p.m. ET on FOX. The 49ers are 3.5-point favorites, according to the latest 49ers vs. Cardinals odds. The over/under for total points scored is 48.5. Before making any 49ers vs. Cardinals picks, make sure you check out the NFL picks from the SportsLine Projection Model.
The Arizona Cardinals dropped to 3-7 with their 41-22 loss to the San Francisco 49ers, but quarterback Jacoby Brissett was able to make NFL history in the process.