diginomica

Vector search is table stakes - OpenSearch Foundation bets on data sovereignty and enterprise trust instead

OpenSearch Software Foundation Executive Director Bianca Lewis and Governing Board Chair Carl Meadows on why the new ...

Medera Receives FDA Fast Track Designation for Gene Therapy Targeting Duchenne Muscular Dystrophy-Associated Cardiomyopathy

Medera Inc. ("Medera"), a clinical-stage biopharmaceutical company developing next-generation cardiovascular therapeutics, and its clinical development division Sardocor, today announced that the U.S.
eLife

Gelsolin Counteracts ER Stress-Driven Inflammatory Circuits in Psoriasis-like Dermatitis

This paper provides a valuable observation that imiquimod, a compound often used to induce a psoriasis-like skin inflammation in mice, has a TLR7-independent effect acting through the unfolded protein ...
Technology Networks

COVID-19 Vaccine Vector Repositioned for Cancer and Gene Therapies

Researchers developed a gorilla adenovirus platform with inherent tumor selectivity, lung tropism, and large-gene capacity.

VectorBuilder Introduces High-Stability MuteFree™ AAV to Improve Gene Therapy Manufacturing Reliability

VectorBuilder, a global leader in gene delivery technologies and CDMO solutions, today announced MuteFree™ AAV, a ...
BioWorld

Vector-mediated LDLR/TF expression in muscle reduces atherosclerosis in LDLR-deficient mice

In previous work, researchers from CEINGE (Naples, Italy) and collaborating institutions developed an alternative gene therapy strategy based on the expression of a secreted fusion protein, including ...
eLife

A simplified and highly efficient cell-free protein synthesis system for prokaryotes

The study presents valuable findings of an optimized E. coli cell-free protein synthesis (eCFPS) system that has been simplified by reducing the number of core components from 35 to 7; furthermore, ...
BioProcess International

Optimizing Expression Vectors for Biotherapeutic Protein Production: Design Principles, Titer-Influencing Factors, and Promoters

All aspects of upstream bioprocessing are under pressure to increase expression titers and improve product quality (PQ). To date, major advancements in the glutamine synthetase (GS) system for Chinese ...
IEEE

Construction of a Eukaryotic Expression Vector pEGFP-C1-BMP-2

Abstract: It has been known that bone morphogenetic proteins not only play important role in bone development, but also induce tumorigenesis and promote tumor spread. However, the molecular mechanisms ...