The San Francisco 49ers defense will face Philip Rivers on Monday night. The 44-year-old recently came out of retirement to ...

INDIANAPOLIS — The Indianapolis Colts and San Francisco 49ers understand the stakes on Monday night. Both find themselves in ...

San Francisco 49ers TE George Kittle, RB Christian McCaffrey, and DL Keion White discussed the energy inside the locker room, ...

San Francisco 49ers head coach Kyle Shanahan highlighted Indianapolis' run defense, reflected on overcoming injuries, and ...

The San Francisco 49ers have a big Week 16 Monday Night Football clash against the Colts, and here are bold predictions.

Let’s keep the streak going. We have found some success with our NFC West Bold Predictions, but now the heat is on. The Los ...

Brock Purdy and the San Francisco 49ers will play the Indianapolis Colts at Lucas Oil Stadium on ESPN on Monday, December 22, ...

The Indianapolis Colts are just trying to get into the playoffs. The San Francisco 49ers are playing for a division title and ...

Lucas Oil Stadium is the location where the Indianapolis Colts (8-6) will meet the San Francisco 49ers (10-4) on Monday.

On one hand, there was speculation of a quarterback controversy, as 49ers backup quarterback Mac Jones performed increasingly ...

The 49ers re-sign quarterback Adrian Martinez to the practice squad and work out two offensive linemen as they assess roster ...

QB Mac Jones could draw major offseason trade interest after impressing in relief of Brock Purdy, according to an NFL insider ...