San Francisco's star-studded offense, finally whole, aims to dominate a struggling Panthers squad searching for a breakthrough win.

Jacoby Brissett completed an NFL-record 47 passes, but San Francisco's offense rolled in Purdy's first game in weeks.

The San Francisco 49ers had huge plays on both sides of the ball to earn a blowout win over the Arizona Cardinals. Here are the highlights.

The 49ers have six players on their report with injuries, and five have no game status designation while fully practicing Friday. Only starting cornerback Deommodore Lenoir is questionable. He was added to the report as limited Thursday with a calf injury suffered in practice and did not practice Friday.

DraftKings has them at -750 and FanDuel has them at -590. The implied odds on that are 88% and 85% respectively. NFL.com has a playoff projection system that gives them an 86% chance of making it, while ESPN FPI has them at 90%. Lastly, FTN, the home of DVOA, has them at 86% and the Athletic has matched that in their projections as well.

The San Francisco 49ers announced they have signed QB Adrian Martinez to the practice squad and released RB Sincere McCormick from the practice squad. Martinez (6-2, 220) originally entered the NFL after signing with the Detroit Lions as an undrafted free agent on May 12,

The San Francisco 49ers will hold three full practices this week as they prepare for their Week 11 matchup against the Arizona Cardinals. Head coach Kyle Shanahan, defensive coordinator Robert Saleh, and offensive coordinator Klay Kubiak are scheduled to speak with the media....

The San Francisco 49ers have been able to maintain a good run defense even when their pass defense has fallen apart. The team still ranks 11th overall in expect