THE beginning clinical clerk, the house officer and the practicing physician are all confronted with conditions that are frustrating in every phase of medical action. The purpose of this article ...

Alex Keuroghlian is an associate professor of psychiatry at Harvard Medical School and the director of the Division of Public and Community Psychiatry at Massachusetts General Hospital. Stephen ...

Why are trials of de-escalation of therapy being conducted for early-stage breast cancer? Axillary nodal status in invasive breast cancer has long been regarded as one of the most important ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when ...

Hospital studies suggest that scrub typhus is a leading cause of severe undifferentiated fever in regions across Asia where the disease is endemic, but the population-based incidence of infection ...

A 72-year-old woman with type 2 diabetes had somnolence after a urologic procedure for bladder cancer. She had respiratory acidosis and anion-gap metabolic acidosis. A diagnosis was made.

A 46-year-old patient presented to a clinician to request initiation of estrogen therapy. . . . Each interactive case presents an evolving patient history and a series of questions and exercises ...

A 2-year-old boy presented with a 1-week history of itchy, red spots. Tense vesicles, erosions, and inflammatory plaques were seen. Direct immunofluorescence revealed a linear band of IgA at the ...

Research, discussion, and analysis to inform emerging public health issues.

Taking a more evidence-based approach to work design may help to bridge the growing divide between U.S. clinicians and organizational leaders, reducing “administrative harm.” ...

Bacterial vaginosis affects one third of reproductive-aged women, and recurrence is common. Evidence of sexual exchange of ...