The 49ers did allow the Cardinals offense to be on the field for 82 plays, and Jacoby Brissett did pass for 452 yards, but that was partially because San Francisco had multiple shorter fields from the turnovers, and Arizona was playing from behind all day.

The San Francisco 49ers and Arizona Cardinals face off in Week 11 of the NFL today. Here's where to watch and start time

Expert recap and game analysis of the San Francisco 49ers vs. Arizona Cardinals NFL game from November 16, 2025 on ESPN.

He’s such an irreplaceable figure in the locker room and one of, if not the greatest tight end ever to wear the red and gold.

The Arizona Cardinals were beaten 41-22 by the San Francisco 49ers on Sunday at State Farm Stadium. A lot of thing went wrong. However, moving the ball offensively wasn't one of the problems. They had a season-high 488 yards of offense. They outgained the 49ers 488 to 281 in yards.

Kickoff from State Farm Stadium is set for 4:25 p.m. ET on FOX. The 49ers are 3.5-point favorites, according to the latest 49ers vs. Cardinals odds. The over/under for total points scored is 48.5. Before making any 49ers vs. Cardinals picks, make sure you check out the NFL picks from the SportsLine Projection Model.

An injured Kyler Murray, a depleted backfield and really, inconsistent football. It didn’t stop today either in their loss to the San Francisco 49ers in Week 11. Let’s take a look at some key stats that led to the Cardinals' seventh loss of the season:

Last week, the San Francisco 49ers were on the outside looking in at the NFC playoff picture after a disappointing loss to the Los Angeles Rams. But with Brock Purdy returning from injury and delivering a strong performance,