By far, the worst unit on the San Francisco 49ers is their pass rushers. Injuries have decimated this area. They don’t have Nick Bosa and rookie Mykel Williams

San Francisco 49ers wide receiver Ricky Pearsall has missed the team's first practice of the week due to knee and ankle injuries.

George Kittle explained why former San Francisco 49ers defensive tackle DeForest Buckner is one of his favorite teammates.

The San Francisco 49ers might have a new face at linebacker when they visit the Indianapolis Colts in Week 16.

Brandon Aiyuk has not played this season after suffering a torn ACL and MCL in Week 7 of the 2024 campaign, and San Francisco 49ers head coach Kyle Shanahan said Thursday he hasn't heard much from the wide receiver since the setback.

On Wednesday, JSerra Catholic High School in San Juan Capistrano announced that the school had hired Hardy Nickerson as its new head coach. Nickerson, who was a star linebacker in the NFL in the 1990s, just won a California Interscholastic Federation Division 5-AA state championship at Bishop O'Dowd High School in Oakland last weekend.

The 49ers’ playoff picture will be dramatically impacted by tonight’s NFC West battle in Seattle between the Seahawks and the Rams.

The Indianapolis Colts and San Francisco 49ers understand the stakes Monday night. Both teams find themselves in the throes of tight division races where one more loss could eliminate them.

See who's in and who's out for the Week 16 matchup between the San Francisco 49ers and Indianapolis Colts on December 22, 2025.

The San Francisco 49ers defense has been surviving despite injuries, and a lot of that credit has been given to Robert Saleh. Saleh was always expected to use the 49ers as a pit stop to regain his strong reputation as a head coaching candidate and parlay this into a new job.