Chimeric antigen receptor (CAR) T cells targeting CD19 have transformed the treatment of B-cell cancers, but many patients do not have long-term remission. We designed an anti-CD19 enhanced ...

The aldosterone synthase inhibitor lorundrostat may be an effective treatment for uncontrolled, treatment-resistant hypertension. New research findings are summarized in a short video.

Obicetrapib is a highly selective cholesteryl ester transfer protein inhibitor that reduces low-density lipoprotein (LDL) cholesterol levels. The efficacy and safety of obicetrapib have not been ...

A total of 181 patients underwent randomization and received at least one dose of efruxifermin or placebo. Of these patients, liver biopsy was performed in 154 patients at 36 weeks and in 134 ...

Smoldering multiple myeloma is an asymptomatic precursor of active multiple myeloma. Daratumumab monotherapy may help prevent progression to active myeloma in patients with smoldering disease.

Shown are the genetic variants identified in EPO, the gene encoding erythropoietin (EPO), in patients with erythrocytosis. The term cDNA denotes complementary DNA, F female, M male, and NA not ...

Mycobacterium tuberculosis continues to cause substantial illness globally. The efficacy of BCG revaccination for the prevention of sustained M. tuberculosis infection is unclear. New research ...

The benefits of automated insulin delivery are well established in type 1 diabetes, but its efficacy and safety in type 2 diabetes have been uncertain. New research findings in patients with type ...

Lepodisiran is a long-duration small interfering RNA that inhibits hepatic production of apolipoprotein(a). New research findings on lepodisiran in patients with elevated lipoprotein(a ...

In patients with COPD, eosinophilic inflammation leads to exacerbations, with increased use of health care resources and mortality. New research findings with mepolizumab treatment are summarized ...