The San Francisco 49ers beat the Arizona Cardinals on Sunday at State Farm Stadium. How did it affect their standing heading into Week 12?

DraftKings has them at -750 and FanDuel has them at -590. The implied odds on that are 88% and 85% respectively. NFL.com has a playoff projection system that gives them an 86% chance of making it, while ESPN FPI has them at 90%. Lastly, FTN, the home of DVOA, has them at 86% and the Athletic has matched that in their projections as well.

CBS Sports draft analyst Mike Renner has released his fourth 2026 NFL mock draft, projecting that the San Francisco 49ers will address one of their most pressing needs.

Arizona had the passing game working, but it didn't matter in a 41-22 loss to San Francisco at State Farm Stadium in Glendale.

Jason Pinnock was benched after Week 5, but he has played 80 snaps in the 49ers' dime look since then. However, he has not been good in that role. Pinnock allowed five catches, including a touchdown, in his expanded role against the Arizona Cardinals. That should signal a time to switch things up, as he was one of the few issues in that game.

Kickoff from State Farm Stadium is set for 4:25 p.m. ET on FOX. The 49ers are 3.5-point favorites, according to the latest 49ers vs. Cardinals odds. The over/under for total points scored is 48.5. Before making any 49ers vs. Cardinals picks, make sure you check out the NFL picks from the SportsLine Projection Model.

The Arizona Cardinals dropped to 3-7 with their 41-22 loss to the San Francisco 49ers, but quarterback Jacoby Brissett was able to make NFL history in the process.

Albert Breer and Kyle Brandt argue that San Francisco 49ers coach Kyle Shanahan deserves consideration for the 2025 NFL Coach of the Year award.