Unfolded peptides and proteins exhibit a remarkable degree of structural diversity that defies the notion of a simple random coil. Recent investigations have elucidated that even in their so-called ...

Harvard and Northwestern researchers combine AI and physics to design unstable proteins that comprise the dark proteome.

Healthy cells are constantly breaking down proteins and building up new ones with the help of enzymes aptly named unfoldases, because they unravel proteins tagged for destruction or recycling. Now, a ...

ALS, also known as Lou Gehrig's disease, is among the most challenging neurological disorders: relentlessly progressive, ...

DnaK/DnaJ or Trigger factor and find that chaperone dependence during primary biogenesis in vivo does not track with ...

Researchers showed that large motor neurons face high metabolic stress, making them more prone to degeneration. Reducing this ...

The paper, “ Intrinsically accelerated cellular degradation is amplified by TDP-43 loss in ALS-vulnerable motor neurons in a zebrafish model ,” suggests that the cellular degradation load linked to ...

In order to fulfill their many functions, proteins must be folded into the correct shape. Researchers at the University of Basel have now discovered tiny "folding factories" in cells that enable ...

In order to fulfil their many functions, proteins must be folded into the correct shape. Researchers at the University of Basel have now discovered tiny “folding factories” in cells that enable ...

More than 150 years after amyotrophic lateral sclerosis (ALS) was first described, the disease remains one of the most ...