"We are targeting dysregulated RNA polymerase I (Pol I) transcription in MYC-driven cancers," the company noted. "Pol I transcription of ribosomal RNA genes (rDNA) is tightly regulated downstream of ...

Ribosomes are the cell's protein factories, which read the genetic code and assemble the proteins that every organism needs ...

Researchers at the Johns Hopkins Kimmel Cancer Center and Department of Radiation Oncology and Molecular Radiation Sciences uncovered a new tumor-suppressive response that could lead to novel ...

Oceans churned with lava. Air filled thick with smoke. Asteroids stormed down incessantly. Life during the Hadean Eon four billion years ago was a struggle, and yet that was when it began. 1,2 With no ...

We’re celebrating 180 years of Scientific American. Explore our legacy of discovery and look ahead to the future. In 1957, just four years after Francis Crick and other scientists solved the riddle of ...

How does a cell know when it’s been damaged? A molecular alarm, set off by mutated RNA and colliding ribosomes, signals danger. When the sun shines on your skin, what does it hit? When it causes a ...

Proteins sourced from microorganisms are attracting attention for their potential in biomanufacturing a variety of products, ...

In the microscopic world of bacteria, gene transfer is a powerful mechanism that can alter cellular function, drive antibiotic resistance and even shape entire ecosystems. Now an interdisciplinary ...