Many positive strand RNA viruses encode helicases, but their distinct functions in viral replication cycles is poorly understood. Here, we identify a mutation in the helicase domain of HCV ...

Antiretroviral therapy (ART) halts HIV-1 replication but is not curative due to the persistence of HIV-1 in a stable latent reservoir in long-lived resting memory CD4 + T cells 1,2,3,4,5,6. In people ...

A team of scientists at the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg and the University of Regensburg has unveiled insights into how HIV-1, the virus responsible for ...

For decades scientists have recognized that human immunodeficiency virus (HIV) is a formidable viral pathogen. After years of probing work and extensive experimentation, a Yale research team has ...

Bacteriophages, or phages for short, are viruses that infect bacteria. Using phages therapeutically could be very useful in fighting antibiotic-resistant pathogens, but the molecular interactions ...

Viruses are entirely dependent on their hosts to reproduce. They ransack living cells for parts and energy and hijack the host's cellular machinery to make new copies of themselves. Herpes simplex ...

A study reveals how two proteins cooperate in a key early step of antiviral detection, as reported by researchers at Science Tokyo. Using cryo-electron microscopy and high-speed atomic force ...

Hepatitis B virus, a killer of more than one million people each year, is a notoriously wily virus, often lingering and resurfacing even after treatment. But, thanks to a new class of drugs, its luck ...

Recent research showed that an artificially constructed RNA self-replicating system modeling primitive life at the origin of life evolved to become more prone to extinction under certain experimental ...