Most current medicines are derived from naturally occurring small molecules. Yet the lack of a systematic method for producing diverse nature-inspired small molecules has prevented the development of ...

Immune checkpoint inhibitors (ICIs) emerged in the US about 15 years ago as an exciting class of cancer treatments that have ...

Rapamycin essentially signals to mTOR to send out the message to slow down and do some clean-up (autophagy). This makes cells better at responding to stress and presses pause on unchecked cell growth, ...

Dietary restriction has long been one of the most robust, evidence-backed methods to extend lifespan across multiple species. But if the idea of prolonged fasting or reduced calorie intake sounds ...

Ciclosporin is used as an immunosuppressive agent in the treatment of IBD, but can cause severe adverse effects, including kidney and nerve damage. In addition, patients with IBD are at risk of ...

New research points to the drug rapamycin as a potential treatment for kidney disease. The study builds on past research and shows that studies performed on mice are more likely to translate to humans ...

Rapamycin is a drug used to suppress the immune system in transplant patients, but scientists have found that it may have another use. The drug has been shown to have anti-aging properties, despite no ...

A few years back, Matt Kaeberlein was diagnosed with a frozen shoulder. "It was really bad," he recalls. He wasn't sleeping well and couldn't throw a ball due to the pain. His doctor recommended ...

See Momo run faster, farther and with far more vigor, energy and youthfulness, his owners say, now that he’s taking a drug meant for humans with cancer. “It’s been remarkable,” Paola Anderson said as ...

Rapamycin shows promise in animal models, suggesting anti-aging potential Human trials are underway to explore its effects on aging-related diseases Side effects are manageable at lower doses, but ...

The scientist discusses several reasons, including fear of the actual and fictional side effects of rapamycin, everolimus and other clinically-approved drugs, arguing that no real side effects ...

Rapamycin and several analogs, such as CCI-779 and RAD001, are currently undergoing clinical evaluation as anticancer agents. In this study, we show that inhibition of mammalian target of rapamycin ...