Fluorescent probes have emerged as indispensable tools in the detection and imaging of nucleic acids, underscoring advances in both fundamental research and clinical diagnostics. By conjugating ...

The detection of nucleic acids is important for many life science research tasks, such as sequencing, cDNA synthesis and cloning, RNA transcription and transfection. DNA/RNA concentration is often ...

A plethora of chemical or enzymatic methods are available to generate nucleic acids such as those labeled with fluorophores, enzymes and radioactive phosphates, or nucleotides modified with ...

A new single-stranded DNA probe lights up when it binds just one copy of viral RNA inside a cell (Anal. Chem., DOI: 10.1021/ac3023873). Such a probe could help biologists study the progression of ...

A team of researchers have developed an easy-to-use colorimetric assay for the detection of food contaminated with salmonella. The assay is based on a novel nucleic acid probe that is cleaved by an ...

pt. I. Design of energy transfer probes. Selection of fluorophore and quencher pairs for fluorescent nucleic acid hybridization probes / Salvatore A.E. Marras -- Choosing reporter-quencher pairs for ...

Multiplexed and quantitative analysis of nucleic acid sequences in complex mixtures is essential in various applications of microbiological research. We have developed a method based on solution ...

Nucleic acids may be labeled at their 3’ end, 5’ end, or throughout the molecule, depending on the desired application. Myriad of enzymatic or chemical methods are utilized to generate nucleic acids ...

Clinical Infectious Diseases, Vol. 27, No. 5 (Nov., 1998), pp. 1171-1180 (10 pages) Since 1992 two new nucleic acid-based tests (Gen-Probe Pace 2 and Abbott LCR) for the diagnosis of Neisseria ...

A literature review of a paper where the authors describe a method that can make FISH procedures more sensitive and specific. This article* describes a strategy to improve the sensitivity and ...