Mixed histiocytosis (Langerhans cell histiocytosis [LCH] / Erdheim-Chester disease [ECD]) developing after treatment for ...

In contrast to most dendritic-cell populations, Langerhans cells repopulate locally throughout life in the steady state, independently of any input from the blood circulation. In contrast to quiescent ...

Some people might say that Paul Langerhans Jr. was destined to make many contributions to medicine because he was born into a family of physicians and scientists. He made his first major contribution ...

More than half-a-century after the fact, it’s still the look in his father’s eyes that John Langerhans remembers. It was a look that led Langerhans to a lifetime of playing and coaching baseball, ...

Figure 2: Fusion of Mo-DCs from healthy donors or individuals with LCH, in the presence of IL-17A, with or without IFN-γ. We used transwells to determine whether the IL-17A secreted by DCs from the ...

Miriam Merad; Petra Hoffmann; Erik Ranheim; Sarah Slaymaker; Markus G Manz; Sergio A Lira; Israel Charo; Donald N Cook; Irving L Weissman; Samuel Strober; Edgar G Engleman To explore the roles of host ...

Positron-emission tomographic (PET) images show a single bone lesion involving the humerus (Panel A, arrow); low-risk lesions involving the orbit, lymph nodes, bone (multifocal lesion), and thymus ...

Fifty-four patients from 12 countries took VMF 20 mg/kg/d. They were classified according to risk organ involvement: liver, spleen, and/or blood cytopenia. The main evaluation criteria were adverse ...

Researchers at Yale School of Medicine have demonstrated that Langerhans cells in the skin, which had been thought to alert the immune system to pathogens, instead dampen the skin's reaction to ...

Pulmonary Langerhans'-cell histiocytosis is an uncommon interstitial lung disease in adults. It has an unpredictable course and may be associated with an increased susceptibility to the development of ...

We report an unusual case of Langerhans cell granulomatosis (LCG) manifested as a villous synovial proliferation in a 38-year-old female jogger. One year after the onset of joint symptoms, she had a ...

Researchers found that Langerhans cells (LCs) play a crucial role in mucocutaneous acute guest-versus-host disease (aGVHD). Their experiments in mice showed that when the LCs of a recipient were ...