Extensive studies have shown that talin is the essential player for inside-out activation of integrins by binding to the intracellular tail of β integrins. Here we show that, while talin binding is ...
Talin, a force-bearing cytoplasmic adapter essential for integrin-mediated cell adhesion, links the actin cytoskeleton to integrin-based cell–extracellular matrix adhesions at the plasma membrane. Its ...
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