Figure 2: Mechanism and selectivity of anti-HLA-DR-induced cell death. As certain hematopoietic stem cells express HLA-DR (refs. 30,31), we investigated possible hematological effects of antibody ...

Although the avoidance of HLA-DRB1 mismatch is associated with improved graft survival rates in children, the likelihood of finding young ABO-matched local donors without DR mismatches is very low, ...

Good HLA-A, HLA-B, and HLA-DR matches do not guarantee rejection-free renal transplantation. Some kidney transplants fail despite such matches, suggesting that other antigens might be targets for ...

Subsets of activated CD8⁺ lymphocytes defined by membrane expression of the activation antigens HLA-DR and CD38 were counted by three-color flow cytometry in homosexual men who subsequently became ...

Metagenomic shotgun sequencing to identify specific human gut microbes associated with immune checkpoint therapy efficacy in melanoma patients. A phase Ib/II dose-escalation study evaluating triple ...

Generation and characterization of antitumor infiltrating lymphocytes from patients with breast cancer for adoptive cell transfer therapy. This is an ASCO Meeting Abstract from the 2017 ASCO-SITC ...

A new HLA class I allele has been linked to a significantly increased risk for allopurinol-induced severe cutaneous adverse reactions.

One main goal of anti-cancer therapies is to kill tumor cells without affecting the surrounding normal cells. Therefore, many drugs are designed to target tumor-specific antigens, which are molecules ...

T Cell Engaging Antigen Presenting Cell Human Leukocyte Antigens (HLA) show foreign protein to T cells. HLA varies from ...

Dapsone is used in the treatment of infections and inflammatory diseases. The dapsone hypersensitivity syndrome, which is associated with a reported mortality of 9.9%, develops in about 0.5 to 3.6% of ...