Group II introns are catalytic RNA molecules that require divalent metal ions for folding, substrate binding, and chemical catalysis. Metal ion binding sites in the group II core have now been ...

The completed sequencing of entire bacterial genomes and recent advances in genomics has allowed the identification of many genes. While several genes have been characterized, the function of the ...

Branching is a critical step in RNA splicing that is essential for 5′ splice site selection. Recent spliceosome structures have led to competing models for the recognition of the invariant adenosine ...

An ancient bacterial enzyme (grey) crawls along a tangled strand of RNA (orange), creating a complimentary strand of DNA (blue). Lambowitz and his team think this enzyme -- called GsI-IIC RT and part ...