Toward the goal of generating high-quality embryo models in vitro, this study establishes a stepwise protocol to derive trophectoderm-like cells from mouse extended pluripotent stem (EPS) cells. These ...
The team mapped the spatial and temporal patterns of glucose uptake using single-cell-resolution imaging of developing mouse embryos, stem cell models, and embryo-derived tissues. They found that the ...
Scientists in the Brivanlou lab used light-inducible gene expression (yellow circle) and embryo models to demonstrate that, at the start of gastrulation, body-axis formation requires an interplay ...
Crosstalk between the embryo and the developing placenta relies on same signal for multiple messages
In mammals, signalling between the placenta and the embryo is essential for successful development. Here, a quantitative, time-resolved model describes the coordinated formation of the mouse embryo ...
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