A previously unknown mechanism required for cells to start proliferating has been identified. A combination of mathematical modelling and cell-based experiments shows that the enzyme WEE1 switches off ...

A newly synthesized bis-coumarinyl methane derivative, 14e, inhibits tyrosinase more potently than kojic acid in laboratory ...

KRAS cancer treatment may have a new upstream target: the METTL13 enzyme that helps tumors overproduce KRAS protein and ...

First publication reveals how roginolisib uniquely locks the cancer-driving enzyme PI3Kδ in an inactive state, differentiating the drug from other PI3Kδ inhibitorsSecond publication outlines ...

Prostate cancer is one of the most common malignancies in men globally. Hormonal therapies targeting the androgen–androgen receptor axis have significantly delayed disease progression. However, drug ...

Lymphomas belong to the group of malignant diseases of the immune system and mainly affect the organs of the lymphatic system. Anaplastic large cell lymphoma (ALCL) belongs to the subgroup of ...

The results of a preclinical study by lymphoma researchers at Weill Cornell Medicine suggest that an emerging class of anticancer drugs called EZH2 inhibitors may greatly enhance the potency of some ...

Researchers at Karolinska Institutet and Lund University in Sweden have identified a new treatment strategy for neuroblastoma, an aggressive form of childhood cancer. By combining two antioxidant ...

A team of researchers from the Hebrew University of Jerusalem, the Weizmann Institute of Science, and the University of Tokyo has made a significant breakthrough in the fight against cancer by ...

A new review maps how ABHD enzymes regulate the reversible lipid modification S-palmitoylation and shape cancer, ...