Adverse drug reactions (ADRs) are a significant cause of hospital admissions and treatment discontinuation worldwide. Conventional approaches often fail to detect rare or delayed effects of medicinal ...

Chemical structures called cyclopropanes can increase the potency of many drugs, but traditional methods to create this structure require highly reactive -- potentially explosive -- ingredients. Now, ...

By restructuring a common chemotherapy drug, scientists increased its potency by 20,000 times. In a significant step forward for cancer therapy, researchers at Northwestern University have redesigned ...

In the late 1950s and 1960s, more than 12,000 malformed babies with short arms and legs were born as a side effect of thalidomide, a drug sold to pregnant women to prevent morning sickness. The ...

A version of this story appeared in Volume 100, Issue 23 And yet a look at drugs that have made it into the clinic reveals that the pharmaceutical industry has explored only a fraction of that ...

The FDA and EMA require CNS penetrant drug candidates to be assessed for abuse potential. As part of this assessment, the chemical similarity to known drugs of abuse is analyzed. Scitegrity Limited ...

WASHINGTON, Aug. 20, 2025 — How do you identify something no one has a test for? Designer drugs replicate the effects of known, illicit drugs but evade law enforcement. The chemical structure ...

Virtual screening methods fall broadly into two categories: ligand- and structure-based. Ligand-based virtual screening doesn’t require a target protein structure, Instead, it leverages known active ...