A new review outlines how the copper-dependent cell death regulator FDX1 may shape prognosis, metabolism, and treatment ...

Research reveals that FDX1 downregulation in acute myeloid leukemia drives resistance to cuproptosis via the ROS/p53/ME1 axis ...

University of Missouri researchers have discovered a new way to harness one of the body's natural defenses: copper. While copper is essential for life and helps power important biological processes, ...

Copper is an essential trace element that underpins key biochemical processes, including mitochondrial respiration, antioxidant defence and connective tissue synthesis. Cellular copper levels are ...

While toxic in high concentrations, copper is essential to life as a trace element. Many tumors require significantly more copper than healthy cells for growth—a possible new point of attack for ...

While toxic in high concentrations, copper is essential to life as a trace element. Many tumors require significantly more copper than healthy cells for growth—a possible new point of attack for ...

Cuproptosis was discovered in 2022. It was a previously unknown type of cell death caused by an excess of copper. The research group led by Professor Johannes Karges at Ruhr University Bochum, Germany ...

A preclinical study from researchers at The University of Texas MD Anderson Cancer Center, published today in Cell, details a connection between the immune system and cuproptosis, a type of ...

Cuproptosis is fundamentally different from all previously known mechanisms of cell death: The deciding trigger is an excess of copper in the cell. It binds to certain proteins in the mitochondria ...