For a living cell to divide successfully, each daughter cell must inherit the correct genetic material. In eukaryotes, segregation of duplicated chromosomes is performed by the mitotic spindle, a ...

Researchers from the Hubrecht Institute's Kops group, in collaboration with researchers from the University of Edinburgh, have made a surprising new discovery in the structure of the centromere, a ...

Three RIKEN researchers have shed light on the cellular mechanisms underlying chromosomal abnormalities that can cause miscarriages and congenital disorders such as Down syndrome. These abnormalities ...

Advancements in genome sequencing have challenged the long-standing belief that the position of the centromere in the chromosome is fixed. Researchers from Okayama University, Japan, have analyzed ...

Despite the immense amount of genetic material present in each cell, around three billion base pairs in humans, this material needs to be accurately divided in two and allocated in equal quantities.

An actomyosin network (PANEM) forms around the nucleus in prophase, and its contraction repositions peripheral and polar chromosomes to facilitate their interaction with the mitotic spindle, ensuring ...

“This work is really important because the X chromosome has largely been excluded from genetic studies in the past,” said Amy Roberts, a molecular epidemiologist at King’s College London who was not ...

Super-resolution microscopy image of a mitotic chromosome (white) with the centromeres of each sister chromatid depicted in orange. Each centromere consists of two distinct chromatin subdomains ...