Chromatin remodelling refers to the dynamic changes in the structure of chromatin, for example the repositioning, removal, and modification of nucleosomes, the structural unit of chromatin. Chromatin ...
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How a histone 'switch' regulates chromatin dynamics
The serine 31 (Ser31) phosphorylation modification (H3.3S31ph) in the N-terminal tail of the histone variant H3.3 can transform H3.3 nucleosomes from a stable state to a dynamically activated ...
The Gates lab studies the intersection between metabolism, chromatin, and gene regulation. We aim to discover how metabolite signaling to chromatin impacts cell and tissue function in health and ...
The tight wrapping of genomic DNA around nucleosomes in the cell nucleus makes it unavailable for gene expression. A team of Ludwig-Maximilians-Universitaet (LMU) in Munich now describes a mechanism ...
Matthew Gage, Ph.D., Department of Chemistry, University of Massachusetts Lowell Juan Artes Vivancos, Ph.D., Department of Chemistry, University of Massachusetts ...
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