The chaperonin GroEL assists protein folding through ATP-dependent, cooperative movements that alternately create folding chambers in its two rings. The substitution E461K at the interface between ...

The chaperonin system is pivotal in maintaining cellular proteostasis through its ATP-dependent mediation of protein folding. Among these, the TRiC/CCT complex has emerged as a key molecular machine ...

Proteins are the molecular building blocks of life. In order to perform a multiplicity of functions in the cell, each protein must adopt a defined three-dimensional structure, similar to components in ...

Scientists have studied molecular interactions in the chaperonin protein GroEL. GroEL is alternately bound and unbound by a co-chaperonin, GroES. Against expectations, the 'football' complex -- where ...

HOUSTON (Jan. 21, 2010) – In proper society of yesterday, the chaperone insured that couples maintained proper courting rituals. In biology, a group of proteins called chaperonins makes sure that ...

Analyzing ring moiety additions to the A-ring of camptothecin. This is an ASCO Meeting Abstract from the 2015 ASCO Annual Meeting I. This abstract does not include a full text component.

Researchers have found a new way to track metastatic cancer cells in the body, which in the future could help identify cancer earlier and give patients more treatment options. UCF researchers have ...

Cryo-electron tomography, or cryo-ET for short, can be used to visualize and analyze cellular structures in their natural environment. Researchers at the Max Planck Institute of Biochemistry (MPIB) in ...