A growing number of women with chronic inflammatory diseases are continuing to use TNF inhibitors throughout pregnancy.

Overall, 503 patients received first-line TNF inhibitors, of whom 261 switched to upadacitinib, while 128 switched to another TNF inhibitor and 114 switched to another mechanism of action.

Observational data in inflammatory bowel disease (IBD) supported the safety of JAK inhibitors versus TNF inhibitors in terms of serious outcomes -- including blood clots, major heart events, and ...

Tumor necrosis factor inhibitor use in patients with IMIDs did not increase the risk of de novo heart failure or worsen existing heart failure.

In moderate to severe Crohn's disease, a network meta-analysis suggested that TNF inhibitor-based therapy was the most ...

Tapering TNF inhibitors is safe and maintains low disease activity for 2 years in psoriatic arthritis and axial ...

Juvenile idiopathic arthritis, older age, and concomitant immunomodulation delay the onset of psoriasiform dermatitis in ...

Tofacitinib shows no evidence of an increased risk for malignancies compared with TNF inhibitors when used to treat RA, according to data derived from Khosrow-Khavar F, et al. Arthritis Rheumatol ...

As second-line therapy for PsA and axSpA, no clear treatment-retention benefit at 3 years was seen when swapping to a bDMARD with another MOA.

However, that same analysis in JAMA Network Open found that use of TNF inhibitors was ultimately not associated with a higher risk for all-cause mortality (aHR 1.02, 95% CI 0.86-1.21).

Tumor necrosis factor (TNF) inhibitors for rheumatoid arthritis were linked with a lower risk of Alzheimer's disease and related dementia, but only in people with cardiovascular disease, data from ...

Megan E.B. Clowse, MD: TNF inhibitors are a class of medications that have now been on the market for 20 years and have really revolutionized the management of inflammatory arthritis. These ...