San Francisco 49ers starting quarterback Brock Purdy won't be active again Sunday vs. the Los Angeles Rams according to a report.

In Sunday's showdown at Levi's Stadium, the Rams looked like they were on their way to a big win after jumping out to a 21-0 lead thanks to touchdowns on their first three drives, but the 49ers stuck around. They scored 14 straight points to make it a one-possession game just after halftime, finding a rhythm on offense with Mac Jones airing it out.

Matthew Stafford completes passes to eight receivers and throws touchdowns to four different players, becoming the fourth Ram and seventh quarterback in NFL history to throw four touchdowns in

Expert recap and game analysis of the Los Angeles Rams vs. San Francisco 49ers NFL game from November 9, 2025 on ESPN.

Christian McCaffrey #23 of the San Francisco 49ers runs with the ball during the game against the Los Angeles Rams at Levi’s Stadium on November 9, 2025 in Santa Clara, California. Matthew Stafford #9 of the Los Angeles Rams throws during the game against the San Francisco 49ers at Levi’s Stadium on November 9, 2025 in Santa Clara, California.

The NFC West is loaded at the top, and two of the division's contenders meet on Sunday when the 6-3 San Francisco 49ers host the 6-2 Los Angeles Rams. This is the second meeting between these two rivals, as the 49ers won the Week 5 matchup 26-23 in overtime on Thursday Night Football.

Even though the odds of the San Francisco 49ers completing the comeback still would have been slim, Fox’s officiating analyst said the referee crew’s mistake late in Sunday's loss to the Rams took away a key first down.

George Kittle had plenty to say after the San Francisco 49ers' loss to the Los Angeles Rams on Sunday at Levi's Stadium.